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Macrocephaly is a clinical and radiological term that refers to a generalized increase in the size of the cranial vault.
This slightly differs from the term megalencephaly which means an increase in the size of the brain parenchyma.
In some individuals a large head is normal or something that is familial.
However in others it is related to a syndrome, and other features may be present, see long list of causes below.
In an infant it can result from a wide range of causes:
congenital hydrocephalus: this, in turn, can result from a multitude of causes
hydranencephaly: the choroid still forms CSF
metabolic storage diseases, e.g. mucopolysaccharidoses
benign enlargement of the subarachnoid spaces in infancy as a benign cause of macrocephaly
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