Macrocephaly is a clinical and radiological term that refers to a generalized increase in the size of the cranial vault.

This slightly differs from the term megalencephaly which means an increase in the size of the brain parenchyma. 

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In an infant it can result from a wide range of causes:

Some define the condition on skull radiography when the head circumference that is more than 2 standard deviations above the mean or exceeds the 97th percentile by at least 0.5 cm 4.

Malformations of the central nervous system

Article information

rID: 9170
Tag: cases, cases
Synonyms or Alternate Spellings:
  • Large head in infancy

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Cases and figures

  • Case 1: mucopolysaccharidosis
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  • Case 2: achondroplasia
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  • Mucopolysaccharid...
    Case 3: mucopolysaccharidosis
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