Macrocerebellum

Dr Henry Knipe and Dr Bruno Di Muzio et al.

Macrocerebellum, also known as cerebellar hyperplasia, refers to a rare condition characterised by an abnormally enlarged cerebellum with preserved architecture and shape. It is usually demonstrated on imaging with a thickening of the cortical gray matter of the cerebellar hemispheres.

Macrocerebellum is a rare imaging finding, only a few case have been reported 3.  

It is usually dependent on the underlying disease. Hypotonia, ataxia, and ocular movement disorders are related in patients with a isolated macrocerebellum 1,2

The aetiology is unknown. For some authors it is not considered an independent entity, but a manifestation of different conditions 2,3. For others is a cerebellar response to the elaboration of growth factors intended to augment the slow development of cerebral structures 1.

It can be found as an isolated (non-syndromic) condition or as part of well-defined syndrome, such as Costello syndrome and Sotos syndrome, or neurometabolic diseases (e.g. mucopolysaccharidosis type I and II) 2.

There is no malformation, only a diffusely enlarged cerebellum, especially due to cerebellar hemispheres cortical gray matter 2,3.

Share article

Article information

rID: 37974
Section: Pathology
Tag: cases
Synonyms or Alternate Spellings:
  • Cerebellar hyperplasia

Support Radiopaedia and see fewer ads

Updating… Please wait.
Loadinganimation

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.