Macrodactyly is a descriptive term for isolated enlargement of some or all elements of a digit, whether of the hand or foot 1. Often it is equated with its most common cause, macrodystrophia lipomatosa 4. Rarely it can be seen as a form of Proteus syndrome 2
A number of conditions may manifest with asymmetric limb hypertrophy, including:
- neural fibrolipoma 3 (some term any macrodactyly with a neural fibrolipoma as macrodystrophia lipomatosa)
- neurofibromatosis type 1
- macromelia - asymmetric enlargement of entire extremity
- hemihyperplasia (hemihypertrophy) - asymmetric enlargement of one half of body
- 1. P. P. Kotwal et.al, Macrodactyly, J Bone Joint Surg [Br] 1998;80-B:651-3.
- 2. Rosalind B et.al, The Proteus Syndrome: CNS Manifestations, AJNR 19:987–990, May 1998
- 3. Mark D. Murphey et.al, From the Archives of the AFIP, Imaging of Musculoskeletal Neurogenic Tumors: Radiologic-Pathologic Correlation, September 1999 RadioGraphics, 19, 1253-1280.
- 4. Ellise Natividad and Kinna Patel. A Literature Review of Pedal Macrodactyly. The Foot and Ankle Online Journal 3 (5): 2 Full text
- 5. Blacksin M, Barnes FJ, Lyons MM. MR diagnosis of macrodystrophia lipomatosa. AJR Am J Roentgenol. 1992;158 (6): 1295-7. AJR Am J Roentgenol (citation) - Pubmed citation
- 6. Krengel S, Fustes-Morales A, Carrasco D, Vázquez M, Durán-McKinster C, Ruiz-Maldonado R. Macrodactyly: report of eight cases and review of the literature. (2000) Pediatric dermatology. 17 (4): 270-6. Pubmed