Madelung disease

Madelung disease, also known as Madelung-Launois-Bensaude syndrome or neck lipomatosis or multiple symmetric lipomatosis, is a rare benign entity clinically characterised by the presence of multiple and symmetric, non-encapsulated masses of fatty tissue, usually involving the neck and the upper region of the trunk.

It should not be confused with the Madelung deformity of the wrist, which is an epiphyseal growth plate disturbance characterised by dorsal and radial bowing of the radius, or Madelung dyschondrosteosis, a dysplasia associated with the Madelung deformity. 

Furthermore, this is a distinct entity from the similarly named familial multiple lipomatosis with which it is frequently confused in the dermatologic literature

Madelung disease is most commonly seen in the Mediterranean population with a male to female ratio of 15:1. The commonest age of onset is between the third and fifth decades.  

Although the aetiology is unknown, approximately 60-90% of patients present a previous history of moderate to severe alcoholism.

It is mainly deposited along the anterior or posterior subcutaneous tissue of the neck, deep under the sternocleidomastoid and trapezius muscles, posterior cervical triangle, and around the salivary glands 4.

Treatment options include surgical resection (liposuction or conventional surgery), indicated when there is evidence of aerodigestive compression and presence of aesthetic deformities. Recurrence is frequently observed. Abstinence from alcohol is advised if there is a relevant history.

Its first description was in 1846 by Benjamin Brodie. The classical horse collar pattern of cervical lipomas distribution was described by Otto W Madelung in 1888.

Launois and Bensaude concluded the description of the syndrome in 1898, naming it as multiple symmetrical adenolipomatosis.

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Article information

rID: 12161
Tag: cases
Synonyms or Alternate Spellings:
  • Multiple symmetric lipomatosis
  • Multiple symmetrical lipomatosis
  • Benign systemic lipomatosis
  • Lanois-Bensaunde adenolipomatosis
  • Madelung's disease
  • Benign symmetric lipomatosis
  • Madelung-Launois-Bensaude syndrome
  • Madelung-Launois-Bensaude disease

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