Citation, DOI, disclosures and article data
At the time the article was created Donna D'Souza had no recorded disclosures.View Donna D'Souza's current disclosures
Maffucci syndrome is a congenital nonhereditary mesodermal dysplasia characterized by multiple enchondromas with soft-tissue venous malformations and/or spindle-cell hemangiomas 6,7, generally caused by somatic mutations in IDH1 or IDH2 6.
On imaging, it is usually portrayed by a short limb with metaphyseal distortions due to multiple enchondromas, which may appear grotesque, and soft tissue masses with phleboliths depicting venous malformations.
There is a recognized male predilection.
The clinical symptoms of Maffucci syndrome are present at birth or manifest in the 1st year of life in approximately a quarter of cases. In just under half of cases, the onset of symptoms is before the age of 6 years, and in three-quarters of cases, symptoms start before puberty. The venous malformations appear as blue subcutaneous nodules that can be emptied by manual compression. Spindle-cell hemangiomas are generally firmer and non-compressible.
The distribution of enchondromas is similar to Ollier disease with the hands and feet most often being affected. The skeletal and vascular lesions in the extremities are usually asymmetrically distributed, with unilateral changes seen in about 50% of patients.
The venous malformations and/or hemangiomas are mostly located in the subcutaneous soft tissues.
Radiographic appearances are nearly pathognomonic, with multiple enchondromas seen associated with soft tissue swelling and phleboliths.
Treatment and prognosis
When there is a shortening of the involved limb, orthopaedical surgery for limb lengthening is usually performed during childhood.
History and etymology
First described in 1881 (prior to Ollier syndrome) by Angelo Maffucci, an Italian pathologist (1847-1903).
- 1. Murphey MD, Fairbairn KJ, Parman LM et-al. From the archives of the AFIP. Musculoskeletal angiomatous lesions: radiologic-pathologic correlation. Radiographics. 1995;15 (4): 893-917. Radiographics (citation) - Pubmed citation
- 2. Mcdermott AL, Dutt SN, Chavda SV et-al. Maffucci's syndrome: clinical and radiological features of a rare condition. J Laryngol Otol. 2001;115 (10): 845-7. - Pubmed citation
- 3. Unger EC, Kessler HB, Kowalyshyn MJ et-al. MR imaging of Maffucci syndrome. AJR Am J Roentgenol. 1988;150 (2): 351-3. AJR Am J Roentgenol (citation) - Pubmed citation
- 4. Zwenneke flach H, Ginai AZ, Wolter oosterhuis J. Best cases from the AFIP. Maffucci syndrome: radiologic and pathologic findings. Armed Forces Institutes of Pathology. Radiographics. 21 (5): 1311-6. Radiographics (full text) - Pubmed citation
- 5. Angela D. Levy, Robert M. Abbott, Charles A. Rohrmann, Jr., Aletta Ann Frazier, Amir Kende. Gastrointestinal Hemangiomas. (2012) American Journal of Roentgenology. doi:10.2214/ajr.177.5.1771073
- 6. Pansuriya T, van Eijk R, d'Adamo P et al. Somatic Mosaic IDH1 and IDH2 Mutations Are Associated with Enchondroma and Spindle Cell Hemangioma in Ollier Disease and Maffucci Syndrome. Nat Genet. 2011;43(12):1256-61. doi:10.1038/ng.1004 - Pubmed
- 7. ISSVA Classification of Vascular Anomalies ©2018 International Society for the Study of Vascular Anomalies Available at "issva.org/classification" Accessed on 08/31/2022.