Major adverse cardiovascular event

Dr Joachim Feger et al.

Major adverse cardiovascular event (MACE) refers to a combined or composite clinical endpoint that is used for outcome evaluations in clinical trials for cardiovascular research intended as a measure of safety and effectiveness and does not have a specific definition.

In the setting relevant for percutaneous coronary interventions (PCI) a major adverse cardiovascular event (MACE) has been defined relating to the safety and effectiveness of as one of the following 1,2:

Since there is no standard definition of other adverse cardiovascular outcomes as e.g. stroke, heart failure recurrent angina 1,2

History and etymology

The term MACE seems to have originated in the 1990s and was related primarily to percutaneous coronary interventions 1-3.

Article information

rID: 84714
System: Cardiac
Synonyms or Alternate Spellings:
  • Major adverse cardiovascular events (MACE)

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