Male pseudohermaphroditism (MPH) is a variation of gender development.
Pathology
Patients with male pseudohermaphroditism have 46 XY karyotype and may manifest as a female phenotype with various degrees of undervirilization secondary to partial androgen insensitivity.
Causes
- androgen insensitivity syndrome
- Leydig cell failure
- testosterone synthesis defects
- 5-alpha reductase deficiency
- persistent Mullerian duct syndrome
- testicular dysdenesis
- congenital anorchia