Malignant fibrous histiocytoma of the retroperitoneum

Retroperitoneal malignant fibrous histiocytomas are an uncommon tumor overall but are considered as one of the most common types of primary retroperitoneal neoplasms

For a broad discussion of this type of a tumor, which commonly involves the extremities, please refer to the main article on malignant fibrous histiocytoma (MFH).

Retroperitoneal malignant fibrous histiocytomas correspond to approximately 15% of all MFHs 3

They occur with predominance in men.

They are categorized as sarcomas and are often high-grade tumors. 

There are six histological subtypes: storiform, pleomorphic, myxoid, giant cell, inflammatory and angiomatoid. Most metastasize and common sites include lung and lymph nodes.

Imaging is not characteristic and clarification pathologically is required. Reassessment of malignant fibrous histiocytoma diagnosis in some series result in re-classification as dedifferentiated liposarcomas.

25% of cases include dystrophic calcification which is uncommon amongst the remaining primary retroperitoneal malignancies.

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Article information

rID: 6338
Synonyms or Alternate Spellings:
  • Malignant fibrous histiocytoma of the retroperitoneum
  • Malignant fibrous histiocytoma: retroperitoneum
  • Retroperitoneal malignant fibrous histiocytomas

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