Retroperitoneal malignant fibrous histiocytomas are an uncommon tumor overall but are considered as one of the most common types of primary retroperitoneal neoplasms.
For a broad discussion of this type of a tumor, which commonly involves the extremities, please refer to the main article on malignant fibrous histiocytoma (MFH).
Retroperitoneal malignant fibrous histiocytomas correspond to approximately 15% of all MFHs 3.
They occur with predominance in men.
They are categorized as sarcomas and are often high-grade tumors.
There are six histological subtypes: storiform, pleomorphic, myxoid, giant cell, inflammatory and angiomatoid. Most metastasize and common sites include lung and lymph nodes.
Imaging is not characteristic and clarification pathologically is required. Reassessment of malignant fibrous histiocytoma diagnosis in some series result in re-classification as dedifferentiated liposarcomas.
25% of cases include dystrophic calcification which is uncommon amongst the remaining primary retroperitoneal malignancies.
- 1. Nishino Mizuki, Katsumi Hayakawa, Manabu Minami et al. “Primary Retroperitoneal Neoplasms: CT and MR Imaging Findings with Anatomic and Pathologic Diagnostic Clues.” Radiographics 23, no. 1 (January 1, 2003): 45-57. doi:10.1148/rg.231025037.
- 2. Coindre Jean-Michel, Odette Mariani, Frederic Chibon et al. “Most Malignant Fibrous Histiocytomas Developed in the Retroperitoneum Are Dedifferentiated Liposarcomas: A Review of 25 Cases Initially Diagnosed as Malignant Fibrous Histiocytoma.” Mod Pathol 16, no. 3 (0): 256-262. [Link].
- 3. Karki B, Xu YK, Wu YK, Zhang WW. Primary malignant fibrous histiocytoma of the abdominal cavity: CT findings and pathological correlation. (2012) World journal of radiology. 4 (4): 151-8. doi:10.4329/wjr.v4.i4.151 - Pubmed