Malignant mixed Mullerian tumours (MMMT), sometimes referred to as a carcinosarcoma, are uncommon malignancies that can occur anywhere along the female genital tract.
It is comprised of both epithelial (carcinomatous) and stromal (sarcomatous) components.
Implicated risk factors include 1:
- advanced age
- excess oestrogen exposure
- prior pelvic irradiation: estimated in 10-30% of cases
- uterus 1: commonest site (MMMTs account for ~5-8% of all malignant uterine cancers, malignant mixed Mullerian tumour of the uterus
- ovary 2: malignant mixed Mullerian tumour of the ovary
- cervix 3: malignant mixed Mullerian tumour of the cervix
Imaging features are somewhat dependant on location and are best discussed under respective sections. In general, they tend to be large bulky lesions.
Treatment and prognosis
They are aggressive neoplasms and lung, liver and bone are common sites of metastases.
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