Malignant mixed Mullerian tumor of the ovary

Malignant mixed Mullerian tumors (MMMT) of the ovary, also known as carcinosarcoma of the ovary, are a rare type of mixed ovarian tumor with both epithelial and stromal components.

They are very rare and account for less than 1% of all ovarian cancers. Most women are post-menopausal at the time of presentation and usually between their 6th to 8th decades of life.

Patients often present with an abdominal mass, ascites, and anemia. As with other ovarian tumors, the presentation can be vague.

MMMTs are histologically biphasic tumors with both carcinomatous (epithelial) and sarcomatous (stromal) elements.

On imaging, it is not possible to differentiate carcinosarcomas from other ovarian neoplasms, and therefore the diagnosis is essentially based on histopathologic findings. Features common to ovarian neoplasms, in general, may be present.

A high incidence of hemorrhagic ascites has been reported in those with advanced disease 6 reported is >50% of the patients having ascites from the tumors.

They are malignant aggressive neoplasms 1,3 carrying a poor prognosis even despite a combination of surgical debulking, radiation therapy, and chemotherapy. Metastasis generally involves serosal and peritoneal seeding. Median survival rates reported in the literature range ~7-10 months at the time of initial writing 5.

The FIGO system is commonly used for staging: see ovarian cancer staging.

Article information

rID: 15187
System: Gynaecology
Tag: cases, cases
Synonyms or Alternate Spellings:
  • Malignant mixed Müllerian tumour of the ovary
  • Ovarian carcinosarcoma
  • Malignant mixed mesodermal tumour of the ovary
  • MMMT ovary
  • MMMT of the ovary
  • Primary ovarian carcinosarcoma
  • Carcinosarcoma of the ovary

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