Malignant phyllodes tumour

Malignant phyllodes tumours of the breast account for up to a quarter of the phyllodes tumours.

Please, refer to the main article on phyllodes tumours for a general discussion. 

It is generally thought that it is the stromal component that becomes malignant 4. This may account for their haematogenous metastatic pattern.

A substantial overlap in the imaging characteristics has been reported between benign and malignant phyllodes tumours. A tumour diameter of 3 cm or greater has been generally reported to be associated with a higher likelihood of malignancy 3.

Fewer than 20% of the malignant tumours metastasize. When metastatic disease does occur, the metastases usually spread haematogenously to the lungs, pleura, or bone. Surgery is the mainstay of treatment as they are not proven to be sensitive to radiotherapy or chemotherapy.


Breast imaging and pathology
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Article Information

rID: 15265
System: Breast
Section: Pathology
Tag: cases
Synonyms or Alternate Spellings:
  • Malignant phyllodes tumours
  • Malignant phyllodes tumor
  • Malignant phyllodes tumors
  • Malignant phyllodes tumours of the breast
  • Malignant cystosarcoma phyllodes

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