Malignant transformation
Last revised by Mohammad Taghi Niknejad on 17 Jan 2023
Citation, DOI, disclosures and article data
Citation:
Bell D, Niknejad M, Malignant transformation. Reference article, Radiopaedia.org (Accessed on 15 Oct 2024) https://doi.org/10.53347/rID-61898
Permalink:
rID:
61898
Article created:
23 Jul 2018,
Daniel J Bell ◉
Disclosures:
At the time the article was created Daniel J Bell had no recorded disclosures.
View Daniel J Bell's current disclosures
Last revised:
17 Jan 2023,
Mohammad Taghi Niknejad ◉
Disclosures:
At the time the article was last revised Mohammad Taghi Niknejad had no financial relationships to ineligible companies to disclose.
View Mohammad Taghi Niknejad's current disclosures
Revisions:
4 times, by
2 contributors -
see full revision history and disclosures
Systems:
Sections:
Synonyms:
- Transformation to cancer
- Cancer transformation
- Malignancy transformation
- Malignancy progression
- Malignant progression
Malignant transformation is the term given to the process whereby either normal, metaplastic, or benign neoplastic tissue, becomes a cancer. The process usually occurs in a series of steps and the affected tissue gradually accumulates the genetic mutations that express a malignant phenotype. The genetic steps are gradually being elucidated 1.
References
- 1. Pütz SM, Vogiatzi F, Stiewe T, Sickmann A. Malignant transformation in a defined genetic background: proteome changes displayed by 2D-PAGE. (2010) Molecular cancer. 9: 254. doi:10.1186/1476-4598-9-254 - Pubmed
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