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Manganese (chemical symbol Mn) is one of the essential trace elements. It has an important biological role in the synthetic pathway for mucopolysaccharides, and it also is a cofactor for several enzymes.
Manganese has the atomic number 25 with an atomic weight of 54.94. It is a transition metal.
Manganese-55 is the only stable isotope. There are a large number (almost 30) of unstable isotopes, with mass numbers ranging from 44 to 73 8.
Diet, absorption, transport and storage
In the normal human diet, manganese is primarily found in grains, legumes, nuts, fruits and vegetables 3. Enteral manganese is poorly absorbed in the small bowel; variance in oral bioavailability may occur with iron deficiency anemia (increased absorption) and high dietary calcium (decreased absorption). After absorption manganese is distributed widely, circulating primarily bound to erythrocytic hemoglobin.
After transport-mediated hepatocyte uptake manganese is concentrated in bile and subsequently eliminated in the feces.
Manganese is incorporated in numerous metalloproteins involved in lipid, amino acid, and carbohydrate metabolism, and its presence is required for the function of several enzymes of biologic importance, including 10:
HMG CoA reductase
Deficiency is rare and sparsely reported, although the associated clinical features have been reported in studies of dietary manganese deprivation and include:
Toxicity, referred to as manganism, most commonly occurs with occupational exposure to manganese dusts or fumes, and is classically a delayed-onset movement disorder with prominent extrapyramidal features.
- 1. William Alexander Newman Dorland. Dorland's Illustrated Medical Dictionary. (2018) ISBN: 9781416023647
- 2. Li L, Yang X. The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions. (2018) Oxidative medicine and cellular longevity. 2018: 7580707. doi:10.1155/2018/7580707 - Pubmed
- 3. Chen P, Chakraborty S, Mukhopadhyay S, Lee E, Paoliello MM, Bowman AB, Aschner M. Manganese homeostasis in the nervous system. (2015) Journal of neurochemistry. 134 (4): 601-10. doi:10.1111/jnc.13170 - Pubmed
- 4. O'Neal SL, Zheng W. Manganese Toxicity Upon Overexposure: a Decade in Review. (2015) Current environmental health reports. 2 (3): 315-28. doi:10.1007/s40572-015-0056-x - Pubmed
- 5. Greenberg MI, Vearrier D. Metal fume fever and polymer fume fever. (2015) Clinical toxicology (Philadelphia, Pa.). 53 (4): 195-203. doi:10.3109/15563650.2015.1013548 - Pubmed
- 6. Riordan RD, Khonsari M, Jeffries J, Maskell GF, Cook PG. Pineapple juice as a negative oral contrast agent in magnetic resonance cholangiopancreatography: a preliminary evaluation. (2004) The British journal of radiology. 77 (924): 991-9. doi:10.1259/bjr/36674326 - Pubmed
- 7. Gale EM, Wey HY, Ramsay I, Yen YF, Sosnovik DE, Caravan P. A Manganese-based Alternative to Gadolinium: Contrast-enhanced MR Angiography, Excretion, Pharmacokinetics, and Metabolism. (2018) Radiology. 286 (3): 865-872. doi:10.1148/radiol.2017170977 - Pubmed
- 8. Norman E. Holden, Tyler B. Coplen, John K. Böhlke, Lauren V. Tarbox, Jacqueline Benefield, John R. de Laeter, Peter G. Mahaffy, Glenda O’Connor, Etienne Roth, Dorothy H. Tepper, Thomas Walczyk, Michael E. Wieser, Shigekazu Yoneda. IUPAC Periodic Table of the Elements and Isotopes (IPTEI) for the Education Community (IUPAC Technical Report). (2018) Pure and Applied Chemistry. 90 (12): 1833. doi:10.1515/pac-2015-0703
- 9. Brandt M, Cardinale J, Rausch I, Mindt TL. Manganese in PET imaging: Opportunities and challenges. (2019) Journal of labelled compounds & radiopharmaceuticals. 62 (8): 541-551. doi:10.1002/jlcr.3754 - Pubmed
- 10. Robert S. Hoffman, Lewis S. Nelson, MD, Lewis R. Goldfrank et al. Goldfrank's Toxicologic Emergencies, Eleventh Edition. (2019) ISBN: 9781259859618 - Google Books
- 11. Friedman B, Freeland-Graves J, Bales C et al. Manganese Balance and Clinical Observations in Young Men Fed a Manganese-Deficient Diet. J Nutr. 1987;117(1):133-43. doi:10.1093/jn/117.1.133 - Pubmed