Marshall-Smith syndrome (MSS) is a rare genetic syndrome primarily comprising of the triad of facial dysmorphism, failure to thrive and accelerated osseous maturation 5. Many cases, however, have wider clinical spectrum.
- mental retardation
- respiratory difficulties
- most cases are sporadic
Most cases with MSS die do not survive past early infancy, with death often occurring by three years of age, largely due to severe respiratory complications, and infections that may result from them.
It was initially described by R E Marhsall and D W Smith et.al in 1971 2
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