Marshall-Smith syndrome

Marshall-Smith syndrome (MSS) is a rare genetic syndrome primarily comprising of the triad of facial dysmorphism, failure to thrive and accelerated osseous maturation 5. Many cases however have wider clinical spectrum.

  • most cases are sporadic

Most cases with MSS die do not survive past early infancy, with death often occuring by three years of age, largely due to severe respiratory complications, and infections that may result from them.

It was initially  described by R E Marhsall and D W Smith in 1971 2

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rID: 15592
Synonyms or Alternate Spellings:
  • Marshall-Smith (MS) syndrome
  • Marshall-Smith syndrome (MSS)