As of the latest update, Google Chrome and Microsoft Edge have made a breaking change to how file uploads are handled. Once your system installs this update, you will not be able to upload new images. Please use another browser until we can get it fixed.

McCune-Albright syndrome

McCune-Albright syndrome (MAS) (also known as McCune-Albright-Sternberg syndrome) is a genetic disorder characterized by the association of:

Presentation is variable 1:

  • leg pain, limp, pathological fracture: ~ 75%
  • abnormal vaginal bleeding: ~25%
  • coast of Maine cafe-au-lait spots
    • predominantly on back of trunk: ~40% (range 30-50%)
    • often ipsilateral to bone lesions
    • irregular borders
  • hypercortisolism (Cushing syndrome): ~7% 3

MAS results from a sporadically occurring somatic GNAS gene mutation 2

The condition is named after:

  • Fuller Albright (1900-1969), an American endocrinologist 
  • Donovan James McCune (1902-1976), an American pediatrician 
  • Carl Sternberg (1872-1935), an Austrian pathologist 
Bone tumours

The differential diagnosis for bone tumors is dependent on the age of the patient, with a very different set of differentials for the pediatric patient.

Share article

Article information

rID: 6568
Section: Syndromes
Synonyms or Alternate Spellings:
  • McCune-Albright-Sternberg syndrome

Support Radiopaedia and see fewer ads

Cases and figures

  • Case 1
    Drag here to reorder.
  • Case 2
    Drag here to reorder.
  • Case 3
    Drag here to reorder.
  • Case 4
    Drag here to reorder.
  • Case 5
    Drag here to reorder.
  • Updating… Please wait.

     Unable to process the form. Check for errors and try again.

     Thank you for updating your details.