Citation, DOI & article data
Mechanical index is proportional to an ultrasound beam's peak negative pressure (or peak rarefaction pressure).
It is also inversely proportional to the frequency of the beam. Therefore, higher frequencies have a lower mechanical index.
Mechanical index = peak negative pressure / √(center frequency of the US beam)
Mechanical index is an indication of an ultrasound beam's ability to cause cavitation-related bioeffects, and this is currently thought a reasonable proxy for micromechanical damage. It is "strictly a cavitation index," but is meant to be interpreted more broadly as tissue mechanical stress/damage.
Theoretically, if one wished to decrease the mechanical index in a study, one should:
- set the focal zone further away from the transducer
- decrease the ultrasound beam output
Interestingly, a consequence of the relationship between frequency and cavitation is that different bubble sizes are susceptible to cavitation at different frequencies. Two different ultrasound frequencies (e.g. 4 MHz and 9 MHz) cavitate bubbles of different sizes. This is important in contrast-enhanced ultrasound, where cavitation of the bubbles is desired.
In the U.S. the FDA mandates that the mechanical index (MI) be kept below 1.9.
In 2009 the British Medical Ultrasound Society (BMUS) released guidelines for the safe use of diagnostic ultrasound equipment 3. The guidelines also detail recommended exposure time and index values for obstetric and neonatal ultrasound.
For obstetric and neonatal scanning there is no known reason to restrict scanning times with a MI value between 0-0.3. There is possibility of minor damage to the neonatal lung or intestine with MI values between 0.3-0.7 and minimizing exposure time at these values is suggested.
When MI values measure >0.7 there is a risk of cavitation if an ultrasound contrast agent containing gas microspheres is being used. The risk increases with MI values above this threshold.
- 1. Pellerito J, MPH JFPMD. Introduction to Vascular Ultrasonography: Expert Consult - Online and Print, 6e. Saunders. ISBN:143771417X. Read it at Google Books - Find it at Amazon
- 2. Section 7-discussion of the mechanical index and other exposure parameters. American Institute of Ultrasound in Medicine. J Ultrasound Med. 2000;19 (2): 143-8, 154-68. Free text at pubmed - Pubmed citation
- 3. Guidelines for the safe use of diagnostic ultrasound equipment. The British Medical Ultrasound Society (2009). Accessed January 2022. https://www.bmus.org/static/uploads/resources/BMUS-Safety-Guidelines-2009-revision-FINAL-Nov-2009.pdf