Meigs syndrome

Meigs syndrome is defined as the presence of ascites and pleural effusion in association with a benign, usually solid ovarian tumour. In the vast majority (80-90%) of cases, the primary tumour is an ovarian fibroma. Other primary tumours include: 

The pathophysiology of ascites in Meigs syndrome is speculative. It was initially suggested that irritation of the peritoneal surfaces by a hard, solid ovarian tumour could stimulate peritoneal fluid production. The pathophysiology of the pleural effusion is also speculative with some suggesting ascitic fluid being transferred via trans-diaphragmatic lymphatic channels into the pleural space.

The pleural fluid tends to be right sided in a majority (~60-70%) of cases.

The condition is benign and the ascites and pleural effusion resolve after resection of the primary pelvic tumour.

Named after Joe Vincent Meigs (1892-1963), an American (US) obstetrician and gynaecologist  4.

General considerations include:

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Article information

rID: 13407
System: Gynaecology
Synonyms or Alternate Spellings:
  • Meig syndrome
  • Demons-Meigs syndrome
  • Meigs-Cass syndrome
  • Meigs' syndrome

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