Meigs syndrome is defined as the presence of ascites and pleural effusion in association with a benign, usually solid ovarian tumour. In the vast majority (80-90%) of cases, the primary tumour is an ovarian fibroma. Other primary tumours include:
The pathophysiology of ascites in Meigs syndrome is speculative. It was initially suggested that irritation of the peritoneal surfaces by a hard, solid ovarian tumour could stimulate peritoneal fluid production. The pathophysiology of the pleural effusion is also speculative with some suggesting ascitic fluid being transferred via trans-diaphragmatic lymphatic channels into the pleural space.
The pleural fluid tends to be right sided in a majority (~60-70%) of cases.
Treatment and prognosis
The condition is benign and the ascites and pleural effusion resolve after resection of the primary pelvic tumour.
History and etymology
Named after Joe Vincent Meigs (1892-1963), an American (US) obstetrician and gynaecologist 4.
General considerations include:
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