Metachronous primary lung carcinoma
Metachronous primary lung carcinoma of usually referred to tumors with the same histology which are "separated in time" when there has been a disease-free interval between cancers.
It definition as been "variably" defined in literature and can include
- time interval of at least 2 years or the second tumor is found in a different segment, lobe, or lung with no carcinoma in the lymphatics common to both; and there is no evidence of extrapulmonary metastasis at the time of diagnosis 1.
- SEER database recommendation: 2-month period to distinguish between synchronous and metachronous multiple primaries.
- IARC suggestion: registration of synchronous tumors diagnosed in an interval of less than 6 months (or metachronous if more than 6 months) if arising in different sites.
- "the latter two suggestions have been for "any" cancer and not just lung cancer"
Average lifelong rate of developing a "new primary lung cancer" is thought o approximates 1% and 6% per year after radical therapy for non-small-cell lung cancer and small cell lung cancer, respectively 4.
- pulmonary metastasis from original initial lung cancer
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