Methylguanine-DNA methyltransferase (MGMT)

O6-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme which is important in predicting the effects of alkylating chemotherapeutic agents (e.g. temozolomide) in the treatment of glioblastomas (GBM). High activity of MGMT results in reduced efficacy of alkylating agents, and thus is a poor prognostic factor 1

When the MGMT promoter is methylated, there would be a decreased activity of MGMT and thus alkylating agents are more effective. In other words, identification of methylated-MGMT is a positive prognostic factor 1


Astrocytic tumour
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Article Information

rID: 32837
Synonyms or Alternate Spellings:
  • MGMT
  • O6-Methylguanine-DNA methyltransferase (MGMT)
  • O6-Methylguanine-DNA methyltransferase
  • Methylguanine-DNA methyltransferase

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