Michaelis-Gutmann bodies

Last revised by David Luong on 13 Dec 2022

Michaeliis-Gutmann bodies are a histological feature characteristic of malakoplakia, typically seen in mid-stage disease 1,2.

They are 1–10 μm laminated or targetoid basophilic focal inclusions of iron and calcium salts seen on light microscopy. They are also periodic acid–Schiff, and diastase-resistant 1.

They usually occur in the cytoplasm of histiocytes (von Hansemann cells) as well as in the surrounding stroma 1,2.

History and etymology

Michaelis-Gutmann bodies are named after Leonor Michaelis and Carl Gutmann who described the histological characteristics of malakoplakia in 1902, one year after the first description of the disease by von Hansemann 1.

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