Microglia

Microglia are one of the four types of glial cell and are the central nervous system equivalent of monocyte-macrophage system 1,2. During health, they are essentially inactive with small cell bodies and numerous processes extending throughout the local parenchyma 1,2. When presented a condition with an inflammatory component, they are able to migrate to the site of activity and become antigen presenting cells, interacting with arriving T-lymphocytes, and able to phagocytose 2

Embryology

Microglia are of mesenchymal origin, only entering the brain late during fetal development 1

Histology

Microglial cells are small and difficult to identify on routine light microscopy. 

Immunohistochemistry

A number of cell antigens can be targetted to identify these cells, including 1

  • CD68
  • ricinus communis agglutinin

 


Share article

Article Information

rID: 51717
Section: Pathology
Synonyms or Alternate Spellings:

Support Radiopaedia and see fewer ads

Updating… Please wait.
Loadinganimation

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.