Middle cerebellar peduncle sign

The middle cerebellar peduncle (MCP) sign is a feature of a number of conditions, particularly neurodegenerative diseases, and most commonly associated with fragile X-associated tremor/ataxia syndrome (FXTAS) although many other conditions are recognised. 

It represents high T2 signal in the middle cerebellar peduncles, which contain the frontocerebellar tracts (connecting to orbitofrontal and dorsolateral prefrontal cortex) 1

The MCP sign is seen in a number of conditions including 1,2

It can of course also be encountered 'randomly' in diseases that have no particular regional predilection (e.g. stroke, tumour).

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Article information

rID: 45914
Section: Signs
Tag: cases, refs
Synonyms or Alternate Spellings:
  • MCP sign

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Cases and figures

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    Case 1: FXTAS
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    Case 2: FXTAS
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    Case 3: MSA-C
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    Case 4: chasing the dragon
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    Case 5: AICA infarction
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