Midfacial hypoplasia

Last revised by Henry Knipe on 24 May 2021

Midfacial hypoplasia is a type of congenital facial anomaly.


Midfacial hypoplasia can be a feature of a number of congenital syndromic anomalies:


Associated features that may be seen with midfacial hypoplasia include:

Radiographic features


The maxilla-mandible-nasion angle (MMN angle)is formed by two lines - one from the nasion to the anterior surface of the mandible, and another line drawn from the anterior surface of the mandible to the most anterior tip of the maxilla. In midfacial hypoplasia, this angle is ~14º versus normal cases the angle is ~20º 6.

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