Millard-Gubler syndrome
Citation, DOI, disclosures and article data
Citation:
Rezaee A, Sharma R, Qureshi P, et al. Millard-Gubler syndrome. Reference article, Radiopaedia.org (Accessed on 13 Jan 2025) https://doi.org/10.53347/rID-42410
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rID:
42410
Article created:
19 Jan 2016,
Amir Rezaee
Disclosures:
At the time the article was created Amir Rezaee had no recorded disclosures.
View Amir Rezaee's current disclosures
Last revised:
Disclosures:
At the time the article was last revised Rohit Sharma had no recorded disclosures.
View Rohit Sharma's current disclosures
Revisions:
5 times, by
4 contributors -
see full revision history and disclosures
Systems:
Sections:
Synonyms:
- Ventral pontine syndrome
Millard-Gubler syndrome, also known as ventral pontine syndrome, is one of the crossed paralysis syndromes, which are characterized by cranial nerves VI and VII palsies with contralateral body motor or sensory disturbances 1-3.
On this page:
Clinical presentation
- ipsilateral facial and contralateral body hemiplegia due to pyramidal tract involvement 1-3
- isotropism and diplopia that is worsened while the patient looks toward the lesion 1-3
- ipsilateral facial paresis and loss of corneal reflex 1-3
Pathology
Lesions in ventral aspect of the caudal pons involving the fibers of the cranial nerves VI and VII as well as corticospinal tract 1-3.
Etiology
Causes vary by age 1-3:
-
young
- tumor
- demyelination (e.g. MS)
- viral infection (e.g. rhombencephalitis)
-
older
- vascular
Radiographic features
Lesions are in ventral aspect of caudal pons with imaging characteristics depend on underlying cause 1-3.
History and etymology
The syndrome was first described separately by Auguste Millard (1830-1915) and Adolphe-Marie Gubler (1821-1879), French physicians, in 1856 4,5.
References
- 1. Onbas O, Kantarci M, Alper F et-al. Millard–Gubler syndrome: MR findings. Neuroradiology. 2005;47 (1): 35-37. Read relevant article. Accessed on 19/01/2016
- 2. Yasuda Y, Matsuda I, Sakagami T et-al. Pontine infarction with pure Millard-Gubler syndrome: precise localization with magnetic resonance imaging. Eur. Neurol. 1993;33 (4): 331-4. Pubmed citation
- 3. A Matlis. Millard-Gubler syndrome. AJNR Am J; Neuroradiol. 1994;15 (1): 179-181. Read relevant article. Accessed on 19/01/2016
- 4. Millard A. Extrait du rapport de M. Millard sur les observations précédentes. Bull Soc Anat Paris. 1856;31:217-221.
- 5. Gubler A. De l’hémiplégie alterne envisagée comme signe de lésion de la protubérance annullaire. Gaz Hebd Sci Med. 1856;5:7-21.
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