Millard-Gubler syndrome

Dr Craig Hacking and Dr Amir Rezaee et al.

Millard-Gubler syndrome, also known as ventral pontine syndrome, is one of the crossed paralysis syndromes, which are characterised by cranial nerves VI and VII palsies with contralateral body motor or sensory disturbances 1-3.

  • ipsilateral facial and contralateral body hemiplegia due to pyramidal tract involvement 1-3
  • isotropism and diplopia that is worsened while the patient looks toward the lesion 1-3
  • ipsilateral facial paresis and loss of corneal reflex 1-3

Lesions in ventral aspect of the caudal pons involving the fibres of the cranial nerves VI and VII as well as corticospinal tract 1-3

Aetiology

Causes vary by age 1-3:

  • young
  • older
    • vascular

Lesions are in ventral aspect of caudal pons with imaging characteristics depend on underlying cause 1-3.

The syndrome was first described separately by Auguste Millard (1830-1915) and Adolphe-Marie Gubler (1821-1879), French physicians, in 1856 4,5.

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Article information

rID: 42410
Section: Pathology
Synonyms or Alternate Spellings:
  • Ventral pontine syndrome

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