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Millard-Gubler syndrome, also known as ventral pontine syndrome, is one of the crossed paralysis syndromes, which are characterized by cranial nerves VI and VII palsies with contralateral body motor or sensory disturbances 1-3.
- ipsilateral facial and contralateral body hemiplegia due to pyramidal tract involvement 1-3
- isotropism and diplopia that is worsened while the patient looks toward the lesion 1-3
- ipsilateral facial paresis and loss of corneal reflex 1-3
Causes vary by age 1-3:
Lesions are in ventral aspect of caudal pons with imaging characteristics depend on underlying cause 1-3.
History and etymology
The syndrome was first described separately by Auguste Millard (1830-1915) and Adolphe-Marie Gubler (1821-1879), French physicians, in 1856 4,5.
- 1. Onbas O, Kantarci M, Alper F et-al. Millard–Gubler syndrome: MR findings. Neuroradiology. 2005;47 (1): 35-37. Read relevant article. Accessed on 19/01/2016
- 2. Yasuda Y, Matsuda I, Sakagami T et-al. Pontine infarction with pure Millard-Gubler syndrome: precise localization with magnetic resonance imaging. Eur. Neurol. 1993;33 (4): 331-4. Pubmed citation
- 3. A Matlis. Millard-Gubler syndrome. AJNR Am J; Neuroradiol. 1994;15 (1): 179-181. Read relevant article. Accessed on 19/01/2016
- 4. Millard A. Extrait du rapport de M. Millard sur les observations précédentes. Bull Soc Anat Paris. 1856;31:217-221.
- 5. Gubler A. De l’hémiplégie alterne envisagée comme signe de lésion de la protubérance annullaire. Gaz Hebd Sci Med. 1856;5:7-21.