Mineralising microangiopathy

Mineralising microangiopathy is a condition characterized by parenchymal cerebral calcifications, and is usually seen in children as a complication of cranial radiotherapy and chemotherapy 1-2.

Radiographic features

Mineralizing microangiopathy can affect the brain widely, with typical sites involved including 3:

CT

CT typically shows calcification in the affected region.

MRI

MRI is less sensitive as calcifications are generally not well demonstrated on conventional MRI sequences. T2* sequences, particularly susceptibility weighted imaging (SWI) will demonstrate magnetic susceptibility artifacts in affected areas. 

  • T1: may show paradoxical hyperintensity in the region of calcification due to surface relaxation mechanism 2
  • T2: often inapparent on spin echo sequences
  • SWI: signal loss

Differential diagnosis

General imaging differential considerations for corticomedullary calcifications are:

Causes of basal ganglia calcification are discussed separately. 

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Article information

rID: 22812
Tag: cases
Synonyms or Alternate Spellings:
  • Mineralizing microangiopathy
  • Mineralizing angiopathy
  • Mineralising angiopathy

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