Morning glory syndrome (eye)

Morning glory disc anomaly (MGDA),also known as morning glory syndrome, is a rare congenital malformation of the optic nerve which is frequently associated with midline abnormalities of the brain and skull 1.

Morning glory disc anomaly is rare and is more commonly found in females 2.

Patients may be initially referred for leukocoria or strabismus and present with variable visual acuity, which depends on the extent of the optic nerve anomaly. Visual field defects and enlarged blind spots are also common 3.

Morning glory disc anomaly is characterised by an enlarged, funnel-shaped excavation in the optic disc, with peripapillary chorioretinal pigmentary changes and overlying central white glial tuft. The vessels are radially orientated, resembling the petals of the morning glory flower, making it challenging to distinguish the arteriolar and venous circulations 2.

Morning glory disc anomaly has many frequently associated features 1:

The diagnosis of morning glory disc anomaly is based on the clinical and fundoscopic features. However, imaging provides additional information regarding the associated ocular, midline and vascular abnormalities.

MRI is considered the imaging modality of choice 1.

  • T1:
    • a funnel-shaped morphologic pattern of the optic disc with elevation and hyperintensity of the adjacent retinal surface
    • fat within the distal optic nerve sheath
  • T2:
    • abnormal tissue within the distal intraorbital segment of the ipsilateral optic nerve
    • effacement of the subarachnoid space at that level
    • discontinuity of the uveoscleral coat at the optic nerve insertion
  • T1 C+ (Gd):
    • enhancement of the abnormal tissue in the region of the distal optic nerve

As there is no definitive treatment for morning glory disc anomaly, and management should focus on optimisation of visual acuity and prevention of amblyopia 2.

The condition was first described in 1970 by Kindler, and the name stems from the resemblance its fundoscopic features make to the morning glory flower 2.

The primary differential diagnosis is the optic nerve coloboma. Morning glory disc anomaly is almost universally a sporadic condition whereas optic nerve coloboma is commonly familial and may occur in association with multisystem congenital malformation syndromes 1.

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Article information

rID: 8107
Sections: Signs, Syndromes
Synonyms or Alternate Spellings:
  • Morning glory disc anomaly

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Cases and figures

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    Figure 1: morning glory flower
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    Coloboma: T2
    Case 1
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    Abnormal tissue i...
    Case 2
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    Case 2: ICA hypoplasia
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