Multicentric glioblastoma

Multicentric glioblastomas are uncommon and represent tumours which have multiple discrete areas of contrast enhancing tumour without connecting T2/FLAIR signal abnormality. They are considered to represent separate synchronous tumours. It must be noted that as imaging has improved, the frequency with which multicentric gliomas have been identified has reduced, as a result of being able to demonstrate connections between enhancing components more readily. In many cases, the pattern of enhancement strongly suggests that these represent microscopic spread, not seen to be linked by T2 signal abnormality, and thus multifocal rather than multicentric. 

Differential diagnosis

In contrast, multifocal glioblastomas have connecting T2/FLAIR signal abnormality and represent spread of tumour along white matter tracts.

Astrocytic tumour
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Article information

rID: 38146
Tag: refs, cases
Synonyms or Alternate Spellings:
  • Multicentric glioblastomas
  • Multicentric GBM

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