50% OFF! Cervical Spine X-ray Course by Matt Skalski Offer ends Monday

Multicentric reticulohistiocytosis

Multicentric reticulohistiocytosis (MRH), also known as lipoid dermatoarthritis, is a rare systemic disorder.

Multicentric reticulohistiocytosis is considered a form of granulomatous disease 10 characterized by infiltration of multinucleated histiocytes into various tissues, primarily affecting skin and synovium, which results in an erosive, deforming polyarthritis.

There is a recognized associated with various malignancies (up to 25% of cases 9):

It can have similar plain film findings as gout and rheumatoid arthritis, although it is, unlike these two other conditions, associated with joint space widening.

Features are bilateral and symmetric and include:

  • sharply demarcated marginal erosions: can have a strikingly bilateral symmetrical distribution and is often sharply circumscribed and rapidly progressive
  • nodular soft tissue swelling: may be appreciated as prominent, non-calcified nodules of the skin, subcutaneous tissue and tendon sheaths
  • predisposition for interphalangeal joints
  • there can be a tendency toward early and severe atlantoaxial involvement
  • no or mild periarticular osteopenia (unlike rheumatoid arthritis)
  • often a disproportion between severity of joint destruction and mildness of symptoms regardless of therapy.
  • absent or minimal periosteal reaction

Article information

rID: 1694
Tag: cases
Synonyms or Alternate Spellings:
  • Multicentric reticulo-histiocytosis (MCRH)
  • Multi centric reticulohistiocytosis (MRH)
  • Lipoid dermatoarthritis

ADVERTISEMENT: Supporters see fewers/no ads

Cases and figures

  • Case 1
    Drag here to reorder.
  • Case 2: involving hands and feet
    Drag here to reorder.
  • Updating… Please wait.

     Unable to process the form. Check for errors and try again.

     Thank you for updating your details.