Multifocal glioblastoma
Last revised by Bálint Botz ◉ on 9 Jan 2021
Citation, DOI, disclosures and article data
Citation:
Gaillard F, Botz B, Glick Y, et al. Multifocal glioblastoma. Reference article, Radiopaedia.org (Accessed on 03 Oct 2023) https://doi.org/10.53347/rID-38148
Permalink:
rID:
38148
Article created:
Disclosures:
At the time the article was created Frank Gaillard had no recorded disclosures.
View Frank Gaillard's current disclosuresLast revised:
9 Jan 2021, Bálint Botz ◉
Disclosures:
At the time the article was last revised Bálint Botz had no recorded disclosures.
View Bálint Botz's current disclosuresRevisions:
10 times, by 6 contributors - see full revision history and disclosures
Systems:
Synonyms:
- Multifocal glioblastomas
Multifocal glioblastomas are tumors which have multiple discrete areas of contrast-enhancing tumor embedded with, or connected by, T2/FLAIR signal abnormality. Multifocal glioblastomas are considered to be part of the one tumor and are commonly encountered, accounting for 2-20% of all glioblastomas 3,4.
Multifocal glioblastomas have been shown to have a poorer prognosis than solitary tumors 2,3.
Differential diagnosis
This is in contrast to multicentric glioblastomas, which have enhancing foci with normal intervening brain, and are thought to more likely represent synchronous but separate tumors.
Quiz questions
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References
- 1. Zamponi N, Rychlicki F, Ducati A et-al. Multicentric glioma with unusual clinical presentation. Childs Nerv Syst. 2001;17 (1-2): 101-5. Pubmed citation
- 2. Hassaneen W, Levine NB, Suki D et-al. Multiple craniotomies in the management of multifocal and multicentric glioblastoma. Clinical article. J. Neurosurg. 2011;114 (3): 576-84. doi:10.3171/2010.6.JNS091326 - Pubmed citation
- 3. Patil CG, Yi A, Elramsisy A, Hu J, Mukherjee D, Irvin DK, Yu JS, Bannykh SI, Black KL, Nuño M. Prognosis of patients with multifocal glioblastoma: a case-control study. (2012) Journal of neurosurgery. 117 (4): 705-11. doi:10.3171/2012.7.JNS12147 - Pubmed
- 4. Singh G, Mehrotra A, Sardhara J, Das KK, Jamdar J, Pal L, Srivastava AK, Sahu RN, Jaiswal AK, Behari S. Multiple glioblastomas: Are they different from their solitary counterparts?. (2015) Asian journal of neurosurgery. 10 (4): 266-71. doi:10.4103/1793-5482.162685 - Pubmed
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