Multifocal glioblastomas are tumours which have multiple discrete areas of contrast enhancing tumour embedded with, or connected by, T2/FLAIR signal abnormality. They are considered to be part of the one tumour.
Multifocal glioblastomas have been shown to have a poorer prognosis than solitary tumours 2.
This is in contrast to multicentric glioblastomas, which have enhancing foci with normal intervening brain, and are thought to more likely represent synchronous but separate tumours.
- 1. Zamponi N, Rychlicki F, Ducati A et-al. Multicentric glioma with unusual clinical presentation. Childs Nerv Syst. 2001;17 (1-2): 101-5. Pubmed citation
- 2. Hassaneen W, Levine NB, Suki D et-al. Multiple craniotomies in the management of multifocal and multicentric glioblastoma. Clinical article. J. Neurosurg. 2011;114 (3): 576-84. doi:10.3171/2010.6.JNS091326 - Pubmed citation
- WHO classification of CNS tumours
- WHO grading of CNS tumours
- VASARI MRI feature set
- diffuse astrocytoma grading
- grade I:
- grade II:
- grade III
- grade IV:
- glioblastoma vs cerebral metastasis
- radiation-induced gliomas
- gliomatosis cerebri (growth pattern)
- specific locations
- treatment response
- Stupp protocol
- glioma treatment response assessment in clinical trials
- multicentric glioblastoma
- multifocal glioblastoma
- prognostic genetic markers