Citation, DOI & article data
Multifocal glioblastomas are tumors which have multiple discrete areas of contrast-enhancing tumor embedded with, or connected by, T2/FLAIR signal abnormality. Multifocal glioblastomas are considered to be part of the one tumor and are commonly encountered, accounting for 2-20% of all glioblastomas 3,4.
Multifocal glioblastomas have been shown to have a poorer prognosis than solitary tumors 2,3.
This is in contrast to multicentric glioblastomas, which have enhancing foci with normal intervening brain, and are thought to more likely represent synchronous but separate tumors.
- 1. Zamponi N, Rychlicki F, Ducati A et-al. Multicentric glioma with unusual clinical presentation. Childs Nerv Syst. 2001;17 (1-2): 101-5. Pubmed citation
- 2. Hassaneen W, Levine NB, Suki D et-al. Multiple craniotomies in the management of multifocal and multicentric glioblastoma. Clinical article. J. Neurosurg. 2011;114 (3): 576-84. doi:10.3171/2010.6.JNS091326 - Pubmed citation
- 3. Patil CG, Yi A, Elramsisy A, Hu J, Mukherjee D, Irvin DK, Yu JS, Bannykh SI, Black KL, Nuño M. Prognosis of patients with multifocal glioblastoma: a case-control study. (2012) Journal of neurosurgery. 117 (4): 705-11. doi:10.3171/2012.7.JNS12147 - Pubmed
- 4. Singh G, Mehrotra A, Sardhara J, Das KK, Jamdar J, Pal L, Srivastava AK, Sahu RN, Jaiswal AK, Behari S. Multiple glioblastomas: Are they different from their solitary counterparts?. (2015) Asian journal of neurosurgery. 10 (4): 266-71. doi:10.4103/1793-5482.162685 - Pubmed