Multifocal glioblastoma

Last revised by Bálint Botz on 09 Jan 2021

Multifocal glioblastomas are tumors which have multiple discrete areas of contrast-enhancing tumor embedded with, or connected by, T2/FLAIR signal abnormality. Multifocal glioblastomas are considered to be part of the one tumor and are commonly encountered, accounting for 2-20% of all glioblastomas 3,4

Multifocal glioblastomas have been shown to have a poorer prognosis than solitary tumors 2,3

Differential diagnosis

This is in contrast to multicentric glioblastomas, which have enhancing foci with normal intervening brain, and are thought to more likely represent synchronous but separate tumors. 

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Cases and figures

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  • Case 2
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  • Case 4
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  • Case 5: transependymal spread
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  • Case 6
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  • Case 7: glioblastoma NOS
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  • Case 8
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