Multifocal glioblastoma

Last revised by Bálint Botz on 9 Jan 2021

Multifocal glioblastomas are tumours which have multiple discrete areas of contrast-enhancing tumour embedded with, or connected by, T2/FLAIR signal abnormality. Multifocal glioblastomas are considered to be part of the one tumour and are commonly encountered, accounting for 2-20% of all glioblastomas 3,4

Multifocal glioblastomas have been shown to have a poorer prognosis than solitary tumours 2,3

Differential diagnosis

This is in contrast to multicentric glioblastomas, which have enhancing foci with normal intervening brain, and are thought to more likely represent synchronous but separate tumours. 

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