Multifocal glioblastoma

Multifocal glioblastomas are tumors which have multiple discrete areas of contrast-enhancing tumor embedded with, or connected by, T2/FLAIR signal abnormality. Multifocal glioblastomas are considered to be part of the one tumor and are commonly encountered, accounting for 2-20% of all glioblastomas ^3,4. 

Multifocal glioblastomas have been shown to have a poorer prognosis than solitary tumors ^2,3. 

Differential diagnosis

This is in contrast to multicentric glioblastomas, which have enhancing foci with normal intervening brain, and are thought to more likely represent synchronous but separate tumors.