Multinodular and vacuolating neuronal tumours

Multinodular and vacuolating neuronal tumour (MVNT) is a newly recognised cytoarchitectural pattern in the recently revised 2016 edition of the WHO classification of CNS tumours.

Radiologically, MVNTs appear as small 'bubbly' indolent subcortical tumours that sometimes present with seizures. These tumours have been most frequently identified in the temporal lobe, although that is likely to be due to that location being more likely to result in seizures than necessarily a predilection for that lobe 1-4.

The true epidemiology of these tumours is unknown as they have only been recently described and many are asymptomatic and thus likely undiagnosed (or misdiagnosed). Reported cases are mostly in young to middle aged individuals with adult onset epilepsy 1-4

Many of these lesions are probably asymptomatic and may be found incidentally on imaging for other reasons, and have, over the year, been misinterpreted a variety of other lesions (see differential diagnosis below). In some individuals these tumours are epileptogenic. 

Histopathologic hallmark of MVNT consist of neuroepithelial cells with conspicuous stromal vacuolation arranged in nodules principally within the deep cortical ribbon and superficial subcortical white matter 1-3. Immunostaining is positive for synaptophysin, HuC/HuD neuronal antigens and p62 but were negative for other markers (e.g. IDH1, nestin, NeuN, neurofilament, GFAP and CD34) 1-4

Smaller lesions are difficult to identify, but if seen will appear as non-enhancing low attenuation lesions deep to the cortex in the subcortical white matter. 

These tumours appear as a cluster of well circumscribed high T2 signal 'bubbles' located predominantly in the subcortical white matter, but can involve overlying cortex 1,3,4

  • T1: hypointense to adjacent grey and white matter
  • T1 C+:
    • usually no enhancement
    • some faint focal enhancement may be seen 3,4
  • T2: hyperintense to grey and white matter, almost as high as CSF
  • FLAIR: do not suppress

MVNTs appear to be benign tumours with very indolent biological behaviour which can, if asymptomatic, be followed by imaging alone. In symptomatic patients (epileptic) surgical resection often controls seizures, with no tumour regrowth reported 1-4

Possible considerations include

Share article

Article information

rID: 40645
Synonyms or Alternate Spellings:
  • Multinodular and vacuolating neuronal tumours (MVNT)
  • MVNT
  • Multinodular and vacuolating neuronal tumor (MVNT)
  • Multinodular and vacuolating neuronal tumour (MVNT)
  • Multinodular and vacuolating neuronal tumors (MVNT)
  • Multinodular and vacuolating neuronal tumour
  • Multinodular and vacuolating neuronal tumor

Support Radiopaedia and see fewer ads

Cases and figures

  • Drag
    Case 1
    Drag here to reorder.
  • Drag
    Cluster of T2 hyp...
    Case 2
    Drag here to reorder.
  • Drag
    Hyperintense to t...
    Case 3
    Drag here to reorder.
  • Updating… Please wait.

    Alert accept

    Error Unable to process the form. Check for errors and try again.

    Alert accept Thank you for updating your details.