Multiple endocrine neoplasia type IIa

Last revised by Mohammad Taghi Niknejad on 18 Jul 2023

Multiple endocrine neoplasia (MEN) type IIa, also known as Sipple syndrome, accounts for most cases of MEN2 and is characterized by:


  • PMP



A small proportion of individuals have a RET D631 proto-oncogene mutation. RET mutation is different from the RET translocation in papillary thyroid carcinoma. The chromosome locus is 10q11.2. 3

See also

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