Multiple endocrine neoplasia type IIa

Dr Henry Knipe and A.Prof Frank Gaillard et al.

Multiple endocrine neoplasia (MEN) type IIa, also known as Sipple syndrome, accounts for most cases of MEN2 and is characterized by:


  • PMP



A small proportion of individuals have a RET 631 proto-oncogene mutation.

See also

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Article information

rID: 1621
System: Head & Neck
Section: Syndromes
Synonyms or Alternate Spellings:
  • MEN IIa
  • Multiple endocrine neoplasia type IIa
  • MEN 2a
  • Sipple syndrome

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Cases and figures

  • Adrenal Phaeochro...
    Case 1: pheochromocytoma
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