Multiple endocrine neoplasia (MEN) type IIb, also known as MEN type 3 (MEN3) 3 or mucosal neuroma syndrome 2, accounts for only 5% cases of MEN2 and is characterised by:
- phaeochromocytoma(s): in 50% of patients, often bilateral, and can be extra-adrenal
- medullary thyroid cancer: 100% of patients; aggressive, and may secrete calcitonin
- mucosal neuroma(s) / ganglioneuroma(s)
- marfanoid habitus
Mnemonic:
- PMMM
See also
- MEN1 (Wermer syndrome)
-
MEN2 (multiple endocrine adenomatosis)
- MEN2a (Sipple syndrome)
- MEN2b (mucosal neuroma syndrome)
- familial medullary thyroid carcinoma
- MEN4
- Carney complex