Myasthenia gravis

Myasthenia gravis (MG) is the most common neuromuscular junction disease and presents with increasing fatigue brought on by exertion. 

Incidence is estimated at 15-20 per 100,000 1,2. Females are more affected (3:1) under the age of 40, but males are more affected by the age of 50 2

Most patients present with ocular symptoms (e.g. diplopia), with the majority (80%) proceeding to experience generalised weakness 1

Myasthenia gravis is an autoimmune disease with anti-AChR and/or anti-MuSK antibodies affecting postsynaptic acetylcholine receptors or muscle specific tyrosine-kinase, respectively 1,2

Along with corticosteroids, immunosuppressant drugs (e.g. cyclosporin, cyclophosphamide, azathioprine) have traditionally been the mainstays of disease-modifying therapy for the disease. Mycophenolate mofetil (MMF) has been traditionally used to treat myasthenia gravis 6. Other treatments include orally active cholinesterase inhibitors such as Mestinon TM (pyridostigmine bromide). 

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Article information

rID: 41664
Synonyms or Alternate Spellings:
  • Myasthenia gravis (MG)

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Cases and figures

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    Case 1: with thymoma
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