Myxoinflammatory fibroblastic sarcoma

Myxoinflammatory fibroblastic sarcoma (MIFS) is an uncommon intermediate grade fibroblastic/myofibroblastic tumour. 

It typically affects adults.

The patient may present with painless swelling.

This tumour is microscopically characterised by solid nests of atypical spindle and epithelioid cells in a myxoid stroma accompanied by dense inflammatory infiltrates. 

It most commonly occurs in the distant extremities. The fingers are a particularly common site of occurrence (which is then called acral myxoinflammatory fibroblastic sarcoma)

MRI features can have some variation 3. Usually seen as a poorly circumscribed mass involving an underlying tendon sheath in the distal extremities. Can often have a multinodular appearance.

It generally carries relatively good prognosis with a long life expectancy although frequent local recurrence can occur 4

It was first described in 1998 by Meis-Kindblom and Montgomery et al.

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Article information

rID: 41951
Tag: cases
Synonyms or Alternate Spellings:
  • Myxoinflammatory fibroblastic sarcomas
  • Myxo-inflammatory fibroblastic sarcoma
  • Myxoinflammatory fibroblastic sarcoma (MIFS)

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