Myxoinflammatory fibroblastic sarcoma

Myxoinflammatory fibroblastic sarcoma (MIFS) is an uncommon intermediate grade fibroblastic/myofibroblastic tumour. 

It typically affects adults.

The patient may present with painless swelling.

This tumour is microscopically characterised by solid nests of atypical spindle and epithelioid cells in a myxoid stroma accompanied by dense inflammatory infiltrates. 

It most commonly occurs in the distant extremities. The fingers are a particularly common site of occurrence (which is then called acral myxoinflammatory fibroblastic sarcoma)

MRI features can have some variation 3. Usually seen as a poorly circumscribed mass involving an underlying tendon sheath in the distal extremities. Can often have a multinodular appearance.

It generally carries relatively good prognosis with a long life expectancy although frequent local recurrence can occur 4

It was first described in 1998 by Meis-Kindblom and Montgomery et al.

Share article

Article information

rID: 41951
Tag: cases
Synonyms or Alternate Spellings:
  • Myxoinflammatory fibroblastic sarcomas
  • Myxo-inflammatory fibroblastic sarcoma
  • Myxoinflammatory fibroblastic sarcoma (MIFS)

Support Radiopaedia and see fewer ads

Updating… Please wait.
Loadinganimation

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.