Myxoinflammatory fibroblastic sarcoma

Last revised by Henry Knipe on 8 May 2023

Myxoinflammatory fibroblastic sarcoma is an uncommon intermediate-grade fibroblastic/myofibroblastic tumor. 

When occurring the finger, the term acral myxoinflammatory fibroblastic sarcoma is used.

It typically affects adults.

The patient may present with painless swelling.

This tumor is microscopically characterized by solid nests of atypical spindle and epithelioid cells in a myxoid stroma accompanied by dense inflammatory infiltrates. 

It most commonly occurs in the distant extremities. The fingers are a particularly common site of occurrence.

MRI features can have some variation 3. Usually seen as a poorly circumscribed mass involving an underlying tendon sheath in the distal extremities. Can often have a multinodular appearance.

It generally carries relatively good prognosis with a long life expectancy although frequent local recurrence can occur 4

It was first described in 1998 by Meis-Kindblom and Montgomery et al.

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