N-acetylcysteine (NAC) is often used as a prophylaxis against contrast-induced nephropathy. Protocols for administration vary widely from institution to institution and the true efficacy is still controversial.
A typical protocol is 1,2:
- 600 mg acetylcysteine twice daily on the day of the examination
- +/- 600 mg twice daily the day before the examination
N-acetylcysteine also forms a key part of the specific treatment of acetaminophen overdose, helping the body to replenish its NAPQI stores.
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