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Revision 9 for 'Neoplasms of the appendix'

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Neoplasms of the appendix

There are a number of neoplasms that can involve the appendix, some of which are peculiar to this site.


Tumors involving the appendix have been found in only about 1% of all appendectomy 9. Epithelial neoplasms and neuroendocrine tumors represent the gross majority of the tumors affecting the cecal appendix

Clinical presentation

Symptoms may vary from patients being completely asymptomatic, such as in small benign neuroendocrine tumors, to a clinical picture of acute appendicitis, which is reported in ~40% of cases and most commonly seen associated with neuroendocrine tumors 9

Mucinous neoplasms can lead to abdominal pain, gastrointestinal obstruction, and abdominal distension when evolving to a pseudomyxoma peritonei

Carcinoid syndrome related to malignant neuroendocrine tumors is rare, present in less than 5% of patients with this tumor. 

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