Neuritic plaques

Neuritic plaques (also known as senile plaques) are a feature of Alzheimer's disease. They are extracellular and composed of a central core of beta-amyloid peptides aggregated together with fibrils of beta-amyloid, dystrophic neurites, reactive astrocytes, phagocytic cells, and other proteins and protein fragments derived from degenerating cells or liberated from neurons 1.

They should not be confused with neurofibrillary tangles which are intracytoplasmic.

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Article Information

rID: 13477
Section: Pathology
Synonyms or Alternate Spellings:
  • Senile plaque
  • Neuritic plaque

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