Neuritic plaques

Neuritic plaques (also known as senile plaques) are pathological extracellular aggregates formed around a core of amyloid β peptide and are a hallmark of Alzheimer's disease

They should not be confused with neurofibrillary tangles which are intracytoplasmic.

Pathology

Neuritic plaques are extracellular and are composed of two components, a central core surrounded by a corona 1,2

The central core is composed of an aggregate of extracellular beta-pleated amyloid, composed of amyloid β Peptide. It demonstrates apple-green birefringence after Congo red stain and fluoresces after thioflavin S staining 2

The corona, which surrounds the central core, is composed of degenerating neurones (primarily axons) containing tau protein and ubiquitin.

Share article

Article information

rID: 13477
Section: Pathology
Synonyms or Alternate Spellings:
  • Senile plaque
  • Neuritic plaque

Support Radiopaedia and see fewer ads

Updating… Please wait.
Loadinganimation

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.