Neuroendocrine carcinoma of the cervix

Last revised by Rohit Sharma on 19 Feb 2023

Neuroendocrine carcinoma of the cervix is a rare type of invasive cervical cancer. These are very aggressive tumors with rapid lymph nodal metastasis 1,2.

Neuroendocrine carcinomas of the cervix account for approximately ~2% of tumors of the cervix seen in the females of reproductive age group 1,2. Neuroendocrine tumors of the cervix are related to human papillomavirus type 18. 

Neuroendocrine carcinomas of the cervix may be classified into small cell, large cell, and other types (which are rare) which include carcinoid, and atypical carcinoid tumor.

In line with the aggressive nature of neuroendocrine tumors, a multimodality approach of a chemotherapeutic regimen of etoposide and cisplatin, and in cases of recurrent disease topotecan, paclitaxel, and bevacizumab followed by radiation and radical surgery may be included in treatment. The prognosis of this carcinoma is very poor with mean survival is up to ~36 months 3-5.

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