Neurofibrillary tangles (NFTs) are abnormal cytoplasmic accumulations of tau proteins, found in neuronal and glial cells of the central nervous system. They are responsible for a number of neurodegenerative diseases (collectively known as tauopathies) including 1:
Neurofibrillary tangles are also a prominent feature of Alzheimer disease, which in addition demonstrates extracellular neuritic plaques.
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