Neurofibromatosis type 1: breast manifestations

Dr Jeremy Jones and Radswiki et al.

Breast manifestations of Neurofibromatosis type 1 (NF1), or von Recklinghausen disease, it is characterised by multiple subcutaneous neurofibromas affecting the breast. 

For a general discussion of the underlying condition, please refer to the article on neurofibromatosis type 1

Radiographic features


Mammographically they appear as well-defined benign appearing masses, often multiple. They are classically peri-areolar in location. Portions of the outline may be rimmed by air density reflecting their superficial nature (giving a halo). These multiple skin lesions can mimic and partially obscure breast lesions on mammogram.

Breast ultrasound

Sonographically neurofibromas are usually seen as well-defined hypoechoic masses with posterior acoustic enhancement located in the subcutaneous tissue with features somewhat similar to a fibroadenoma.

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Article Information

rID: 15410
System: Breast
Tags: stub, cases
Synonyms or Alternate Spellings:
  • Neurofibromatosis affecting the breast
  • Neurofibromatosis of the breast
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    Case 1
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     Case 2
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    Case 3: neurofibromas and breast cancer
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