Neurofibromatosis type 1 (breast manifestations)
Breast manifestations of neurofibromatosis type 1 (NF1), or von Recklinghausen disease, it is characterized by multiple subcutaneous neurofibromas affecting the breast.
For a general discussion of the underlying condition, please refer to the article on neurofibromatosis type 1.
Mammographically they appear as well-defined benign-appearing masses, often multiple. They are classically peri-areolar in location. Portions of the outline may be rimmed by air density reflecting their superficial nature (giving a halo). These multiple skin lesions can mimic and partially obscure breast lesions on mammogram.
Sonographically neurofibromas are usually seen as well-defined hypoechoic masses with posterior acoustic enhancement located in the subcutaneous tissue with features somewhat similar to a fibroadenoma.
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- 2. Hillier JC, Moskovic E. The soft-tissue manifestations of neurofibromatosis type 1. Clin Radiol. 2005;60 (9): 960-7. doi:10.1016/j.crad.2005.02.008 - Pubmed citation
- 3. Porter GJ, Evans AJ, Lee AH et-al. Unusual benign breast lesions. Clin Radiol. 2006;61 (7): 562-9. doi:10.1016/j.crad.2006.02.008 - Pubmed citation
- 4. Gokalp G, Hakyemez B, Kizilkaya E et-al. Myxoid neurofibromas of the breast: mammographical, sonographical and MRI appearances. Br J Radiol. 2007;80 (958): e234-7. doi:10.1259/bjr/33539044 - Pubmed citation
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