Neurolymphomatosis
Updates to Article Attributes
Neurolymphomatosis is a rare condition characterised by the direct invasion of the cranial and peripheral nerves and roots by lymphoma, in the great majority B-cell non-Hodgkin lymphoma.
It should be differentiated from other non-tumour conditions associated with lymphoma that also affect the peripheral nervous system, such as irradiation, chemotherapy, or paraneoplastic effects.
Epidemiology
Neurolymphomatosis seems to be the least common neurologic manifestation of lymphoma 3.
Clinical presentation
The symptoms may vary broadly, including painful plexopathy, cranial nerve palsies with or without pain, painful or painless mononeuropathy, and foot drop 1,3.
Radiographic features
MRI
Brain or spinal MRI can spot a nerve or root enlargement and/or enhancement 1,3, sometimes with a nodular thickening.
-<p><strong>Neurolymphomatosis </strong>is a rare condition characterised by the direct invasion of the cranial and peripheral nerves and roots by <a href="/articles/lymphoma">lymphoma</a>, in the great majority B-cell <a href="/articles/non-hodgkin-lymphoma">non-Hodgkin lymphoma</a>.</p><p>It should be differentiated from other non-tumour conditions associated with lymphoma that also affect the peripheral nervous system, such as irradiation, chemotherapy, or paraneoplastic effects.</p><h4>Epidemiology</h4><p>Neurolymphomatosis seems to be the least common neurologic manifestation of lymphoma <sup>3</sup>.</p><h4>Clinical presentation</h4><p>The symptoms may vary broadly, including painful plexopathy, cranial nerve palsies with or without pain, painful or painless mononeuropathy, and foot drop <sup>1,3</sup>.</p><h4>Radiographic features</h4><h5>MRI</h5><p>Brain or spinal MRI can spot a nerve or root enlargement and/or enhancement <sup>1,3</sup>, sometimes with a nodular thickening.</p>- +<p><strong>Neurolymphomatosis </strong>is a rare condition characterised by the direct invasion of the cranial and peripheral nerves and roots by <a href="/articles/lymphoma">lymphoma</a>, in the great majority B-cell <a href="/articles/non-hodgkin-lymphoma">non-Hodgkin lymphoma</a>.</p><p>It should be differentiated from non-tumour conditions associated with lymphoma that also affect the peripheral nervous system, such as irradiation, chemotherapy, or paraneoplastic effects.</p><h4>Epidemiology</h4><p>Neurolymphomatosis seems to be the least common neurologic manifestation of lymphoma <sup>3</sup>.</p><h4>Clinical presentation</h4><p>The symptoms may vary broadly, including painful plexopathy, cranial nerve palsies with or without pain, painful or painless mononeuropathy, and foot drop <sup>1,3</sup>.</p><h4>Radiographic features</h4><h5>MRI</h5><p>Brain or spinal MRI can spot a nerve or root enlargement and/or enhancement <sup>1,3</sup>, sometimes with a nodular thickening.</p>
Systems changed:
- Spine