Nipple adenoma is a rare, benign breast lesion which often mimics a malignancy
Patient presents with bloody discharge from an ulcerated and painful nipple in one breast. There is itching associated with this lesion. Symptoms may show variation with the menstrual cycle. There may enlargement of nipple and sometimes a mass may be palpated.
Can occur in any age group but most often seen in the age group of 40-50 years. It is seen in both females and males (<5%).
A well circumscribed and unencapsulated lesion.
Glands with stromal fibrosis and epithelial hyperplasia.
Usually small in size lesions, which are not picked up on ultrasound. If seen they are seen as indistinct mass in the region of nipple.
Mostly seen as a small (0.5 -1.5 cm), well-circumscribed nodule in the superficial part of the nipple with homogeneous echogenicity. On doppler these lesions are hypervascular. Doppler sonography may also aid in diagnosis, since most of these entities are hypervascular.
Treatment and prognosis
It is believed to be a premalignant lesion. Complete excision with a narrow rim of uninvolved breast tissue is adequate treatment.
- 1. HANDLEY RS, THACKRAY AC. Adenoma of nipple. Br. J. Cancer. 1998;16: 187-94. Free text at pubmed - Pubmed citation
- 2. Kijima Y, Matsukita S, Yoshinaka H et-al. Adenoma of the nipple: report of a case. Breast Cancer. 2006;13 (1): 95-9. Pubmed citation
- 3. Scott P, Kissin MW, Collins C et-al. Florid papillomatosis of the nipple: a clinico-pathological surgical problem. Eur J Surg Oncol. 1991;17 (2): 211-3. Pubmed citation
- 4. Brownstein MH, Phelps RG, Magnin PH. Papillary adenoma of the nipple: analysis of fifteen new cases. J. Am. Acad. Dermatol. 1985;12 (4): 707-15. Pubmed citation