Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Knipe H, Luong D, et al. Nitrofurantoin related lung changes. Reference article, Radiopaedia.org (Accessed on 05 Jul 2024) https://doi.org/10.53347/rID-70134
Disclosures:
At the time the article was last revised Henry Knipe had the following disclosures:
- Radiopaedia Events Pty Ltd, Speaker fees (past)
- Integral Diagnostics, Shareholder (ongoing)
- Micro-X Ltd, Shareholder (ongoing)
These were assessed during peer review and were determined to
not be relevant to the changes that were made.
View Henry Knipe's current disclosures
Nitrofurantoin related lung disease refers to a spectrum of lung changes that can be precipitated by nitrofurantoin use.
Nitrofurantoin-induced lung injury is uncommon where a considerable number of reported publications likely reflect the widespread use of the drug rather than the incidence of the complication 7.
Nitrofurantoin can induce
- acute hypersensitivity reaction (occurring around 1-2 weeks after a short course)
- chronic pulmonary reaction (occurring after months to years of exposure) 4
Severe lung changes have been described inclusive of
CT
Several patterns may be observed 5
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1. Naidu GD, Deepthi P, Karthik KR, Das U, Swarnalatha G, Gangadhar T. Nitrofurantoin induced interstitial lung disease. (2014) Indian journal of nephrology. 24 (6): 405. doi:10.4103/0971-4065.143302 - Pubmed
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2. Sakata KK, Larsen BT, Boland JM, Palen B, Muhm JR, Helmers RA, Tazelaar HD. Nitrofurantoin-Induced Granulomatous Interstitial Pneumonia. (2014) International journal of surgical pathology. 22 (4): 352-7. doi:10.1177/1066896913492849 - Pubmed
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3. Hargett CW, Sporn TA, Roggli VL, Hollingsworth JW. Giant cell interstitial pneumonia associated with nitrofurantoin. (2006) Lung. 184 (3): 147-9. doi:10.1007/s00408-005-2574-z - Pubmed
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4. Reynolds TD, Thomas J. Nitrofurantoin related pulmonary disease: a clinical reminder. (2013) BMJ case reports. doi:10.1136/bcr-2013-009299 - Pubmed
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5. Andrew Creamer, Rezaur Abdullah, Ayesha Jameel, Sam Hare, Rama Vancheeswaran. Factors predicting resolution in nitrofurantoin-induced lung disease. (2016) European Respiratory Journal. 48 (suppl 60): PA3921. doi:10.1183/13993003.congress-2016.PA3921
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6. Suhail Basunaid, M. Schoutteten, H. Pilate, R. Sprooten, Gernot Rohde. Nitrofurantoin-induced interstitial lung disease. (2012) European Respiratory Journal. 40 (Suppl 56): P2539.
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7. Santiago E. Rossi, Jeremy J. Erasmus, H. Page McAdams, Thomas A. Sporn, Philip C. Goodman. Pulmonary Drug Toxicity: Radiologic and Pathologic Manifestations1. (2000) RadioGraphics. 20 (5): 1245-59. doi:10.1148/radiographics.20.5.g00se081245 - Pubmed
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8. Bidad K, Harries-Jones R. Nitrofurantoin lung injury. (2004) Age and ageing. 33 (4): 414-5. doi:10.1093/ageing/afh131 - Pubmed
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9. Bhullar S, Lele SM, Kraman S. Severe nitrofurantoin lung disease resolving without the use of steroids. (2007) Journal of postgraduate medicine. 53 (2): 111-3. Pubmed
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