Nodule-in-nodule appearance (liver)

Last revised by Vincent Tatco on 27 Jul 2022

Citation, DOI, disclosures and article data

Citation:

St-Amant M, Tatco V, Di Muzio B, et al. Nodule-in-nodule appearance (liver). Reference article, Radiopaedia.org (Accessed on 16 Apr 2024) https://doi.org/10.53347/rID-26033

DOI:

https://doi.org/10.53347/rID-26033

Permalink:

https://radiopaedia.org/articles/26033

rID:

26033

Article created:

24 Nov 2013, Maxime St-Amant ◉

Disclosures:

At the time the article was created Maxime St-Amant had no recorded disclosures.

View Maxime St-Amant's current disclosures

Last revised:

27 Jul 2022, Vincent Tatco

Disclosures:

At the time the article was last revised Vincent Tatco had no recorded disclosures.

View Vincent Tatco's current disclosures

Revisions:

4 times, by 4 contributors - see full revision history and disclosures

Systems:

Hepatobiliary

Sections:

Signs

Synonyms:

Nodule-in-nodule sign
Nodule-in-nodule appearance
Nodule in a nodule appearance
Nodule in a nodule sign

In hepatic imaging, a nodule-in-nodule appearance represents foci of abnormal arterial enhancement within a liver lesion, in cases of a liver regenerative nodule with a focus of hepatocellular carcinoma or high-grade dysplastic nodule. It is so called because of the nodular arterial enhancement is seen within the main non-enhancing liver nodule (at least in arterial phase).

It may be seen in up to 6% of patients with dysplastic nodules ¹.